The title has been in development for over a decade now, it lost their previous designers millions. The old publishers have bailed on the project last year and sued the old devs for all their bananas for wasting their time, and rightfully so.
And when it does eventually come out, how will it be greeted? If you have a look at the trailers, it looks like nothing more than a generic alien-shooting FPS with regenerating health. We've gotten used to more complex games these days. Duke Nukem is a misogynistic wanker in an era in gaming where we've seen characters with some actual personality. And after the upset GTA made after its hooker-killing, how will DNF look to non-gamers?
So in the end, do we actually want this game to come out? I'd say no. It should have died when the old devs died. Sure Duke Nukem holds a special place in gamers' hearts, but it's passed its age.